Researchers have discovered how certain cells in the intestines of mice delay metabolism and, ultimately, contribute to obesity, diabetes, high blood pressure and arteriosclerosis. Scientists say the results could have important effects in the prevention and treatment of these types of metabolic diseases in humans. The study was funded by the National Heart, Lung and Blood Institute (NHLBI), part of the National Institutes of Health and published in the journal Nature.
“Through this research, we link the dots between metabolic and cardiovascular diseases, and new treatment methods can be developed to treat patients with a variety of related conditions,” said Michael Oliv, an NHLBI program officer. Cardiovascular sciences
The cells are known as intracellular T lymphocytes (or natural IELs) vexgen keto and, when they are not present, the researchers discovered that the mice’s metabolism reaches excessive dimensions.
“Rats are metabolized in excess, and even when they consume a diet rich in fat and sugar, they can resist metabolic diseases such as obesity, high blood pressure, hypercholesterolemia, diabetes and arteriosclerosis,” said lead researcher Philip Sarsky. De, associate professor at Harvard Medical School and Massachusetts General Hospital in Boston.
But when normal IELs are present, the researchers found that they limit the availability of a type of hormone, the GLP-1 enzyme that helps speed up metabolism. By limiting GLP-1, natural IELs, in fact, lower the body’s metabolism and maintain the energy that is obtained from food.